| Titre : | ANALYSE GENOMIQUE POUR LA CARACTERISATION DES GENES IMPLIQUES DANS L'HALOTOLERANCE DANS 4 SOUCHES DE BACILLUS | | Type de document : | thèse | | Auteurs : | BEKKOURI ALAMI ALAE, Auteur | | Année de publication : | 20MM013202424 | | Langues : | Français (fre) | | Mots-clés : | Halotolerance Bacillus Microbial Genomics Comparative genome analysis Whole genome Sequencing Salt stress Halotolérance Bacillus Génomique microbienne Analyse comparative des
génomes Séquençage complet du génome Stress salin تØمل Ø§Ù„Ù…Ù„Ø Ø§Ù„Ø¹ØµÙˆÙŠØ© ،الجينومالميكروبي التØليل المقارنللجينوم تسلسل الجينوم الكامل اإلجهاد الملØÙŠ | | Résumé : | Halotolerance is an essential microbial trait that enables survival and functioning in high-
salinity environments. This adaptive capability is particularly pertinent in Bacillus species,
which are renowned for their robustness and diverse physiological capacities. This study
focuses on the genomic analysis of four halotolerant Bacillus strains, aiming to elucidate the
genetic foundations of their ability to survive and thrive in high-salinity environments. By
employing Whole Genome Sequencing (WGS) and advanced comparative genomic techniques,
we identified and characterized the genes and genomic features responsible for halotolerance.
Our analysis revealed the presence of specific gene clusters, including those involved in
osmoprotectant synthesis, ion transport, and stress response, which are pivotal for maintaining
cellular homeostasis salt stress. Additionally, phylogenetic analysis were performed and
sequence alignment indicated significant genetic divergence among the strains, suggesting
diverse evolutionary strategies for coping with salinity. Comparative genomics highlighted the
presence of unique adaptive genes and mobile genetic elements that may have been acquired
through horizontal gene transfer, further enhancing the halotolerance capabilities of these
Bacillus strains.
The findings from this study offer a comprehensive understanding of the molecular mechanisms
of halotolerance in Bacillus, with potential applications in biotechnology, such as the
development of salt-tolerant crops and bioremediation strategies. This research contributes to
the broader field of microbial adaptation to extreme environments and underscores the
importance of microbial genomic studies in uncovering the genetic basis of environmental
resilience | | Numéro (Thèse ou Mémoire) : | MM0132024 | | Président : | AANNIZ Tarik | | Directeur : | OUEDGHIRI Mouna | | Juge : | ERRAFII Khaoula | | Juge : | KANDOUSSI Ilham | | Juge : | BOUZROUD Sarah |
ANALYSE GENOMIQUE POUR LA CARACTERISATION DES GENES IMPLIQUES DANS L'HALOTOLERANCE DANS 4 SOUCHES DE BACILLUS [thèse] / BEKKOURI ALAMI ALAE, Auteur . - 20MM013202424. Langues : Français ( fre) | Mots-clés : | Halotolerance Bacillus Microbial Genomics Comparative genome analysis Whole genome Sequencing Salt stress Halotolérance Bacillus Génomique microbienne Analyse comparative des
génomes Séquençage complet du génome Stress salin تØمل Ø§Ù„Ù…Ù„Ø Ø§Ù„Ø¹ØµÙˆÙŠØ© ،الجينومالميكروبي التØليل المقارنللجينوم تسلسل الجينوم الكامل اإلجهاد الملØÙŠ | | Résumé : | Halotolerance is an essential microbial trait that enables survival and functioning in high-
salinity environments. This adaptive capability is particularly pertinent in Bacillus species,
which are renowned for their robustness and diverse physiological capacities. This study
focuses on the genomic analysis of four halotolerant Bacillus strains, aiming to elucidate the
genetic foundations of their ability to survive and thrive in high-salinity environments. By
employing Whole Genome Sequencing (WGS) and advanced comparative genomic techniques,
we identified and characterized the genes and genomic features responsible for halotolerance.
Our analysis revealed the presence of specific gene clusters, including those involved in
osmoprotectant synthesis, ion transport, and stress response, which are pivotal for maintaining
cellular homeostasis salt stress. Additionally, phylogenetic analysis were performed and
sequence alignment indicated significant genetic divergence among the strains, suggesting
diverse evolutionary strategies for coping with salinity. Comparative genomics highlighted the
presence of unique adaptive genes and mobile genetic elements that may have been acquired
through horizontal gene transfer, further enhancing the halotolerance capabilities of these
Bacillus strains.
The findings from this study offer a comprehensive understanding of the molecular mechanisms
of halotolerance in Bacillus, with potential applications in biotechnology, such as the
development of salt-tolerant crops and bioremediation strategies. This research contributes to
the broader field of microbial adaptation to extreme environments and underscores the
importance of microbial genomic studies in uncovering the genetic basis of environmental
resilience | | Numéro (Thèse ou Mémoire) : | MM0132024 | | Président : | AANNIZ Tarik | | Directeur : | OUEDGHIRI Mouna | | Juge : | ERRAFII Khaoula | | Juge : | KANDOUSSI Ilham | | Juge : | BOUZROUD Sarah |
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