| Titre : | GENOMIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSIS IN AFRICA REVEALED LINEAGE - DRUG RESISTANCE ASSOCIATION | | Type de document : | thèse | | Auteurs : | EL FATHI LALAOUI YASMINE, Auteur | | Année de publication : | 2022 | | Langues : | Anglais (eng) | | Mots-clés : | Mycobacterium tuberculosis Lineages Drug-resistance Genomic Analysis Africa Mycobacterium tuberculosis Lign ́ees resistance aux antibiotiques Analyse
G ́enomique Afrique المتفطرة السلية السالالت مقاومة األدوية التحليل الجيني إفريقيا | | Résumé : | Tuberculosis is a serious infectious respiratory disease caused by Mycobacterium
tuberculosis.
In this study, we used genomics, to determine the population structure of Mycobacterium
tuberculosis in Africa. Using the MTBseq pipeline, we analyzed samples from 28 different
African countries in order to determine the distribution of Mycobacterium tuberculosis
lineages as well as drug resistance in Africa and to verify the association between the two.
As a result, we have found out that the most dominant lineage is lineage 4 with a prevalence
of 54.33%, followed by lineage 3 (8.62%), 2 and 1 with a percentage of 7.41% and
7.31% respectively. West African lineages 6 and 5 have a prevalence of 3.61% and 1.25%
respectively, while lineage 7 with the lowest percentage of 0.58%.
We have also studied the association between lineages and drug resistance and the p value
for the drugs variable was 0.014 while it was 3.24*10-7
for lineages proving the presence
of an association between them.
Moreover, the number of sensitive and resistant samples was calculated and the result
showcased that the majority (12034) of samples were sensitive, 2512 samples were Multi-
Drug Resistant, 1674 samples are Mono-Drug resistant, 1198 samples are Pre-Extensively Drug
Resistant and 223 are resistant to other drugs. | | Numéro (Thèse ou Mémoire) : | MM0182022 | | Président : | AANNIZ Tarik, | | Directeur : | EL ALLALI Achraf ; LAAMARTI Mariam Co-encadrante | | Juge : | BENTAYEBI Kaoutar |
GENOMIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSIS IN AFRICA REVEALED LINEAGE - DRUG RESISTANCE ASSOCIATION [thèse] / EL FATHI LALAOUI YASMINE, Auteur . - 2022. Langues : Anglais ( eng) | Mots-clés : | Mycobacterium tuberculosis Lineages Drug-resistance Genomic Analysis Africa Mycobacterium tuberculosis Lign ́ees resistance aux antibiotiques Analyse
G ́enomique Afrique المتفطرة السلية السالالت مقاومة األدوية التحليل الجيني إفريقيا | | Résumé : | Tuberculosis is a serious infectious respiratory disease caused by Mycobacterium
tuberculosis.
In this study, we used genomics, to determine the population structure of Mycobacterium
tuberculosis in Africa. Using the MTBseq pipeline, we analyzed samples from 28 different
African countries in order to determine the distribution of Mycobacterium tuberculosis
lineages as well as drug resistance in Africa and to verify the association between the two.
As a result, we have found out that the most dominant lineage is lineage 4 with a prevalence
of 54.33%, followed by lineage 3 (8.62%), 2 and 1 with a percentage of 7.41% and
7.31% respectively. West African lineages 6 and 5 have a prevalence of 3.61% and 1.25%
respectively, while lineage 7 with the lowest percentage of 0.58%.
We have also studied the association between lineages and drug resistance and the p value
for the drugs variable was 0.014 while it was 3.24*10-7
for lineages proving the presence
of an association between them.
Moreover, the number of sensitive and resistant samples was calculated and the result
showcased that the majority (12034) of samples were sensitive, 2512 samples were Multi-
Drug Resistant, 1674 samples are Mono-Drug resistant, 1198 samples are Pre-Extensively Drug
Resistant and 223 are resistant to other drugs. | | Numéro (Thèse ou Mémoire) : | MM0182022 | | Président : | AANNIZ Tarik, | | Directeur : | EL ALLALI Achraf ; LAAMARTI Mariam Co-encadrante | | Juge : | BENTAYEBI Kaoutar |
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