| Titre : | HYPERLIPASEMIA IN SURGICAL INTENSIVE CARE: INCIDENCE, RISK FACTORS, PROGNOSTIC IMPACT. | | Type de document : | thèse | | Auteurs : | REGRAGUI Khalil, Auteur | | Année de publication : | 2024 | | Langues : | Anglais (eng) | | Mots-clés : | Lipase Critically Ill Acute Pancreatitis Organ Dysfunction Lipase Pancréatite aigue Dysfunction d'organe état critique الليباز التهاب البنكرياس الحاد فشل العضو حالة حرج | | Résumé : | Background: In critically ill patients admitted to intensive care units, significant elevation of lipase levels is frequently observed even in patients without history of pancreatic disease and that admitted for other reasons. This raises concerns about the meaning of this enzyme’s elevation and its impact on patient outcomes in this population. This study aims to evaluate the incidence, risk factors, and prognostic impact of hyperlipasemia in critically ill patients admitted to a surgical ICU.
Methods: We conducted a prospective observational study at Mohamed 5 Military Hospital's surgical ICU (mix recruitment of patients surgical and medical). Serum lipase levels were measured bi-weekly for all patients over 18 years old with stays longer than 72 hours, who did not meet any exclusion criteria. Hyperlipasemia was defined as an elevation of serum lipase greater than three times the upper normal threshold. We assessed a wide range of parameters including demographic, clinical, biological, and radiological as well as patient outcomes.
Results: The incidence of hyperlipasemia in our study was 24%. A significant association was found between hyperlipasemia and a history of cardiopathy (p = 0.033, OR = 5.1). Hyperlipasemia patients presented higher length of stay and mechanical ventilation compared to the control group. Additionally, mortality was higher in the hyperlipasemia group, which also showed a greater rate of complications during their stay in intensive care.
Conclusion: The findings suggest a potential link between elevated lipase levels and adverse clinical outcomes (higher complications, length of stay, duration of mechanical ventilation). Thus, hyperlipasemia in critically ill patients seems to reflect severity of critical illness and pancreatic damage in the settings of multiple organ dysfunction rather than isolated pancreatic pathology. | | Numéro (Thèse ou Mémoire) : | M2952024 | | Président : | Hicham BALKHI | | Directeur : | Khalil MOUNIR | | Juge : | TAMZAOURTE Mouna | | Juge : | DAMI Abdellah | | Juge : | EDDERAI Meryem |
HYPERLIPASEMIA IN SURGICAL INTENSIVE CARE: INCIDENCE, RISK FACTORS, PROGNOSTIC IMPACT. [thèse] / REGRAGUI Khalil, Auteur . - 2024. Langues : Anglais ( eng) | Mots-clés : | Lipase Critically Ill Acute Pancreatitis Organ Dysfunction Lipase Pancréatite aigue Dysfunction d'organe état critique الليباز التهاب البنكرياس الحاد فشل العضو حالة حرج | | Résumé : | Background: In critically ill patients admitted to intensive care units, significant elevation of lipase levels is frequently observed even in patients without history of pancreatic disease and that admitted for other reasons. This raises concerns about the meaning of this enzyme’s elevation and its impact on patient outcomes in this population. This study aims to evaluate the incidence, risk factors, and prognostic impact of hyperlipasemia in critically ill patients admitted to a surgical ICU.
Methods: We conducted a prospective observational study at Mohamed 5 Military Hospital's surgical ICU (mix recruitment of patients surgical and medical). Serum lipase levels were measured bi-weekly for all patients over 18 years old with stays longer than 72 hours, who did not meet any exclusion criteria. Hyperlipasemia was defined as an elevation of serum lipase greater than three times the upper normal threshold. We assessed a wide range of parameters including demographic, clinical, biological, and radiological as well as patient outcomes.
Results: The incidence of hyperlipasemia in our study was 24%. A significant association was found between hyperlipasemia and a history of cardiopathy (p = 0.033, OR = 5.1). Hyperlipasemia patients presented higher length of stay and mechanical ventilation compared to the control group. Additionally, mortality was higher in the hyperlipasemia group, which also showed a greater rate of complications during their stay in intensive care.
Conclusion: The findings suggest a potential link between elevated lipase levels and adverse clinical outcomes (higher complications, length of stay, duration of mechanical ventilation). Thus, hyperlipasemia in critically ill patients seems to reflect severity of critical illness and pancreatic damage in the settings of multiple organ dysfunction rather than isolated pancreatic pathology. | | Numéro (Thèse ou Mémoire) : | M2952024 | | Président : | Hicham BALKHI | | Directeur : | Khalil MOUNIR | | Juge : | TAMZAOURTE Mouna | | Juge : | DAMI Abdellah | | Juge : | EDDERAI Meryem |
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